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Description
Phthalates are rapidly metabolized through various pathways, including the kidneys/urine and the liver, and are typically eliminated from the body once exposure ceases
For example, compared with untreated HCC cell lines, 102 significantly upregulated circRNAs were identified in cells treated with the ferroptosis inducer SF (Liu et al., 2020)
This results in the upregulation of inflammatory molecules such as IL-6 and TNF-, which promote chronic inflammation and further enhance the SASP
Sawa, T
