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448 Moreover, energy demand changes dramatically when immune cells shift from a resting state to an active state, which often causes energy deficits when cells become senescent and, consequently, contributes to the metabolic remodeling accompanied by the altered secretion of cytokines, chemokines, and inflammatory mediators

Hyperammonemia disturbs excitatory processes, and can cause seizures, as well as stupor, and is probably involved in mania and depression

SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells

Abstract Glutamine is an essential cerebral metabolite