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In humans, cyanocobalamin must undergo intracellular enzymatic conversion to the active coenzyme formsmethylcobalamin and adenosylcobalaminwhich, depending on the pH environment, can interconvert with hydroxocobalamin (Gherasim et al., 2013), the most common B12 form in both food and human plasma (Obeid et al., 2015)

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In fact, methylcobalamin B12 is so stable in dry form that it can retain its potency at temperatures as high as 315C / 600F

If you are vegan, don't eat enough B12-rich foods, or have other health issues that prevent you from absorbing it effectively, such as pernicious anaemia, you may have a deficiency