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One of the most significant safety considerations in mold detoxification is the risk of a Herxheimer reaction, commonly referred to as a "detox crash" or "die-off." When binders, antioxidants, or antifungals are introduced, they mobilize toxins stored deep within the tissues and begin killing off fungal colonization

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First-pass hepatic metabolism degrades an estimated 6085% of the compound before systemic circulation, requiring oral doses 35 times higher than parenteral routes to achieve comparable plasma concentrations