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doi: 10.1038/s41380-024-02785-1 [DOI] [PMC free article] [PubMed] [Google Scholar] 39.Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S

The molecular mechanism underlying PRIS is currently unknown, although various studies have implicated inhibition of several mitochondrial proteins including carnitine palmitoyl-transferase I and the mitochondrial respiratory chain at complex II and IV, either directly by propofol, or by one of its metabolites 36

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As a specialist knee surgeon in Sydney, Dr Jonathan Negus is comfortable having open conversations about emerging treatments and where they currently fit in evidence-based knee care