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Description
The K m values of the Y398A variant toward tyrosine and DOPA are 5- and 2-fold higher than that of the WT enzyme, respectively
Whenever indicated, 2-month-old mice were fed with standard diet enriched with 1200 ppm mitapivat (corresponding to a dose of 100 mg/kg/d) for up to 6 months (17)
We understand
This epigenetic regulation involves copper-dependent activation of cellular pathways including enhanced DNA repair, increased antioxidant enzyme production, and stimulation of regenerative processes while simultaneously suppressing inflammatory and destructive gene programs
