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Protecting mitochondria should forestall the decrease in age-related decay of these organelles (decrease in gene expression and mitochondrial biogenesis, oxidative stress, apoptosis) and consequent organ failure

Notably, miR-223, which is specifically released by neutrophils, has a protective effect on hepatocytes

The efficacy of these pH-sensitive linkers is fundamentally reliant on the pronounced pH gradient between the neutral bloodstream and the acidic environments of pathogens, a gradient that is typically more stable and distinct than the fluctuations present in the tumor microenvironment (Onc-ADCs) ( 5.2 Pathogen-specific enzymatically cleavable linkers Linkers designed for cleavage by pathogen-specific enzymes exemplify the highest level of selectivity in antibody-drug conjugate design