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With a variety of metal ions that could bind competitively with the chelator (e.g., calcium, magnesium, zinc, copper, manganese, and other metals, that typically exceed concentrations of toxic elements), the identity of the metal predominately bound by a chelating agent depends both upon accessibility of the chelator to the tissues, how strongly the metal is already bound in the tissues, how strongly the metal binds to the chelator, and to some extent the relative quantities of various ions [1]

Functions : Act as hormones and neurotransmitters (regulate metabolism, growth)

In primary SS renal tubulointerstitial injury, CD163-positive cells and high expression of HIF-1 were reported, where HIF-1 could promote macrophage polarization and participate in renal tubular injury, and early intervention to release HIF-1 could improve renal function in patients (197)

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