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Having an additional robust NADPH-independent back-up system for the two NADPH-dependent cytosolic disulfide reductase systems could provide survival advantages in cases of severe oxidative or toxic stresses

In conclusion, our results suggest that SAG administration protects the liver from CCl4 intoxication by restoring the oxidative balance, ameliorating the impairment of mitophagy and leading to reduced inflammation

It represents a promising treatment method that can be used to combat peripheral and central nervous system lesions when regulated by smallmolecule drugs

Nrf2 further plays a role in regulating the regeneration of the redox electron donor NADPH
