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At ED12.5 Grx3 / embryos show no obvious histological abnormalities but are smaller than wild type embryos and later develop haemorrhages in the head

Representative drugs like the highly selective HIF-2 antagonist Belzutifan (MK-6482) [488] inhibit the expression of pro-angiogenic and pro-survival genes, alleviating abnormal metabolic burden and vascular disruption in tumor tissues

Treatment with intramuscular injection of vitamin B12 was initiated (1000 mcg IM twice a week for a month, plus 100 mcg orally per day)

doi:10.1016/j.bbamcr.2004.10.013 (1283) Durlach J
