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In ischaemic stroke, experimental models have demonstrated that Huperzine A attenuates neuronal apoptosis by upregulating Bcl-2, downregulating pro-apoptotic Bax and p53, and inhibiting caspase-3 activation, thereby preserving mitochondrial membrane potential and promoting neuronal survival under hypoxic conditions [35, 44, 46]

It consists of Rhizoma Smilacis Glabrae ( Smilax glabra ), Dioscorea Opposita ( Dioscorea oppositifolia ), Fructus Forsythiae ( Forsythia suspensa ) Rhizoma Dioscoreae Hypoglaucae ( Dioscorea collettii ), Radix Rehmanniae ( Rehmannia glutinosa ), Semen Plantaginis ( Plantago asiatica ), Isatis indigotica Fortune ( Isatis tinctoria ), Rhizoma Alismatis ( Alisma plantago-aquatica ) and Radix Angelicae Sinensis ( Angelica sinensis )