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During the evolution of Cyanobacteria and Proteobacteria, GSH-dependent ROS detoxification systems incorporated enzymes that play crucial roles in these mechanisms and use GSH as a cofactor, such as GSH peroxidases, GSH reductases, glutaredoxins, and GSH-S-transferases [41]

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Wheeler R.T., Fink G.R

Redox Signaling 13 (4), 449465

Data collected from in vitro and in vivo tumor models suggest that these typically take place by means of three mechanisms: the occurrence of specific genetic lesions, including translocations, gene amplifications and activating mutations