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Unlike isogenic cohorts 27,29 , the genetic diversity of the DO cohort led to substantial proteomic and metabolomic variations (Extended Data Fig

Large prospective cohort studies are needed to determine whether microbiota alterations precede the development of FM or arise secondarily during disease progression (76, 109, 123)

Abbreviations ARRIVE: Animal Research Reporting In vivo Experiments guidelines CAT: catalase DPPH: 1, 1-diphenyl-2-picrylhydrazyl EAL: Equisetum arvense L GPx: glutathione peroxidase HAEA: Hydroalcoholic extracts of Equisetum arvense L HTAB: Hexadecyltrimethylammonium bromide IBD: Inflammatory bowel disease IL-1: Interleukin-1 LPO: Lipid peroxidation MDA: Malondialdehyde MPO: Myeloperoxidase OS: Oxidative stress ROS: Reactive oxygen species SOD: Superoxide dismutase TPC: Total phenolic compound UC: Ulcerative colitis HPLC: High-Performance Liquid Chromatography References Mak, W