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Sci Rep 12 , 14047 (2022)

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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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Plasma homocysteine is elevated in COPD patients and is related to COPD severity

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Please speak with your GP, nurse prescriber or private medical consultant for advice on this

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