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4.5 Loss of endothelial monolayer integrity caused by Spike protein Loss of the pulmonary endothelial barrier is one of the most dangerous effects caused by SARS-CoV-2 and several pathways are involved in this effect, most of which are related to S1 protein activity

Hypertensive Retinopathy: This condition results from very high blood pressure and affects both eyes

AAV2, adeno-associated viral type-2

Cells were fixed with 4 % paraformaldehyde (50-980-487, Thermo Fisher Scientific) in MT buffer (30 mM HEPES, pH7.0, 5 mM EGTA, 5 mM MgSO 4 , and 25mM KCl) for 20 minutes in suspension