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The transsulfuration (TSS) route promotes ferroptosis resistance by generating cys from methionine, which is negatively controlled by cysteyl-tRNA synthetase 1 (CARS1) (84, 98)

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This distinct distribution suggests that the organs primarily involved in metabolic and reproductive functions may exhibit varying capacities for the uptake or retention of IGF-1 LR3 in contrast to IGF-I