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Natural canker sore treatment Contains vitamin b12: People with recurring mouth sores have been found to be deficient in vitamin b12 Contains folate: Similar to vitamin b12, folate levels have also been found to be low in patients with recurrent mouth ulcers Contains l-lysine: May be clinically effective in reducing recurrent aphthous ulcers Contains Deglycyrrhizinated licorice (DGL): This form of licorice blocks the metabolism of certain prostaglandins which can improve healing of oral mucosal tissue