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A central feature here is the formation of a multiprotein complex termed the necrosome, which includes, among others, the receptor-interacting protein kinases 1 and 3 (RIP1 and RIP3)98 and activation of the pseudokinase mixed-lineage kinase domain-like protein (MLKL)99

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The RD9 deletion causes further attrition of the B12 pathway, removing the amino terminus of CobL, with likely polar effects on expression of CobM and CobK, and a predictive algorithm based on primary sequence conservation (SIFT