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Mitochondrial dysfunction ( m -Dys)/altered bioenergetics The mitochondrion is the cellular powerhouse involved in oxidative phosphorylation (OXPHOS), ATP synthesis, and regulation of calcium (Ca 2+ ) signaling, redox homeostasis, lipid metabolism, cell differentiation, immune system, apoptosis, and cellular senescence (aging) 155,156
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To define memory T-cells blood samples were triple stained with CD4: FITC (CC8, IgG2a), CD8: Alexa Fluor 647 (CC63, IgG2a), and CD45 RO : RPE (IL-A116, IgG3)
