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Biosci Rep (1985) 5:393400.10.1007/BF01116556 Summary Keywords reactive oxygen species, oxidative stress, metabolism, T cell, antioxidant Citation Rashida Gnanaprakasam JN, Wu R and Wang R (2018) Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity

Role of Magnesium in Vitamin D Activation and Function

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Toxic bile salts retention in the liver is accompanied by intracellular metabolic disorders, inflammation and reduced detoxification capacity [176], which may enhance the generation of oxidative stress and the accumulation of ROS and RNS in hepatocytes [177], leading to generalized systemic damage to major organs, starting from the liver and reaching the brain, heart, intestine, and kidney [178,179,180]