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4.3 Mechanisms of Mn 2+ activation of cGAS-STING pathway Mn 2+ can enhance the nucleotide transferase (NTase) activity of cGAS to substrate, especially the homologous substrate ATP/GTP

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Glutamine is one of the most abundant nonessential amino acids in the bloodstream (produced by the human body and thus not an essential part of the diet) and contributes to virtually every biosynthetic pathway in proliferating cells

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Understanding the in-depth pharmacology of each neuroprotective compound is essential for the intranasal experimental planning, but it is beyond the scope of this paper to review the in-depth pharmacokinetics and pharmacodynamics (PK-PD) properties of individual compounds

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