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A mammalian variant of GST, GSTP, plays a major role in cancer- development and potential drug/chemotherapeutic resistance in a majority of tumor cell lines: The inhibition of the pro-apoptotic pathway (JNK pathway) and the overexpression of GSTP in tumor cells lead to escape of apoptosis of the tumor cells mediated by non GSTP- substance-drugs Hayes et al.,1995 Josephy,2010 Hayes et al.,2000 Fraser et al.,2003

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Proc Natl Acad Sci U S A 117:38083818 Szentgothai J (1978) The neuron network of the cerebral cortex: a functional interpretation

For example, approximately 27% of SCLC has a SOX2 amplification ( Prominent phenotypic features of small cell lung cancer also lack drug therapy alternatives