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E.C.2.3.3.2) is conserved throughout all three domains of life, ranging from single-celled prokaryotes to multicellular higher eukaryotes (Rawlings et al., 2010)

1 Twenty-seven melasma patients were randomized to receive for eight weeks either 4% niacinamide cream on one side of the face and 4% hydroquinone cream on the other

The protein expression of the IL-36 agonist was verified by immunohistochemical labeling and increased mRNA expression of IL-36 cytokines, particularly IL-36Ra, in psoriatic skin lesions in various cells such as keratinocytes, endothelial cells, dermal fibroblasts, dendritic cells, and CD68 + macrophages