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Based on the strength of the pre-clinical evidence, two randomized double-blind placebo-controlled phase III trials examining the efficacy of subcutaneous rhIGF-I in the treatment of ALS have been completed[335, 336]
Autism Res Treatment 2011
Klinger B Comparison of the growth-promoting effects of insulin-like growth factor I and growth hormone in the early years of life
This complex interplay fosters viral invasion and is pivotal in establishing a neuroinflammatory state [102, 103]
