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Usually, it is distributed within 1 hour of injection

Consistently, metabolomics in primary CLL samples showed that glutamine, rather than glucose, predominantly supports mitochondrial function in MEC-1/N M cases, suggesting a shift away from glucose-driven biosynthesis (Fig

However, there were no significant changes in the levels of cell-associated SIV DNA and SIV RNA between rapamycin-treated rhesus macaques relative to controls during ART, and no significant difference in the time of SIV rebound off ART 182

Once inside astrocytes, glutamate is rapidly converted into glutamine by glutamine synthetase (GS), an essential detoxification step given glutamates potential intracellular toxicity