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Nrf2 not only participates in the regulation of oxidative homeostasis but is also involved in processes related to neuroinflammation and mitochondrial dysfunction, both closely linked to the development of depression (Zuo et al., 2022)
However, oxidative stress also contributes to Met oxidation, which would prohibit conversion of this amino acid to SAM by methionine adenosyltransferase
Rip3 targets pyruvate dehydrogenase complex to increase aerobic respiration in tnf-induced necroptosis
