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Sala M Article: ARCHIVES OF GERONTOLOGY AND GERIATRICS

A key mechanism of L-arginine depletion is upregulation of arginase, an enzyme that competes with eNOS for L-arginine and converts it into urea and L-ornithine

Results show that Mito 10 -NAC is nearly 15002000 times more potent than NAC, and that methylation of the free sulfhydryl group enhanced its antiproliferative effect (the half maximal inhibitory concentration [IC 50 ] for Mito 10 -MeNAC is 1.9 M compared with 9.6 M for Mito 10 -NAC), indicating that the antiproliferative effect is not related to the antioxidant or radical scavenging mechanism