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Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial

The second defense mechanism includes the multidrug efflux protein transporters

Stage 4: Functional Deficiency Severe complications such as B12 deficiency anaemia, nerve damage, and cognitive decline, and common symptoms like: Constant tiredness or fatigue Pale or yellowish skin Numbness or tingling in hands and feet Difficulty walking or balance issues Mood swings, irritability, or depression Memory problems or confusion B12 deficiency hair loss reversible if treated early Swollen tongue or mouth ulcers If left untreated, the effects of vitamin B12 deficiency can include permanent nerve damage and increased risk of heart disease due to high homocysteine levels

Some people notice the energy boost from B12 injections within a few hours