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A recent study has shown that melatonin has the ability to alleviate retinal damage and RGC death and protect against retinal I/R injury by inhibiting TP53-mediated ferroptosis (Zhang et al., 2023)

Plant Cell Physiol 35:539549 Narendra S, Venkataramani S, Shen G, Wang J, Pasapula V, Lin Y, Kornyeyev D, Holaday AS, Zhang H (2006) The Arabidopsis ascorbate peroxidase 3 is a peroxisomal membrane-bound antioxidant enzyme and is dispensable for Arabidopsis growth and development

Metformin has been widely studied for its ability to improve insulin sensitivity and support overall metabolic health