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The metabolic acidosis and the 5-oxoprolinuria in these patients are explained by the decreased feedback inhibition of -glutamylcysteine ligase resulting from the lower GSH levels

In Bacillus megaterium CbiX L , the catalytically important histidine residues are found in the N-terminal domain of the protein (His14 and His79) indicating that this protein has evolved from a fusion of two CbiX S in a different way to CbiK

The high concentration of IL-6 during intensive exercise is due to the fact that this interleukin acts also as a myokine, because it increases exponentially but proportionally to the duration of the exercise and the amount of muscle mass involved in the exercise

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