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Phagocytic cells (e.g., neutrophils and macrophages) show a high concentration of VIC, which stimulates their migration to the site of infection and enhances phagocytosis, oxidant generation, and pathogen killing

4.2.2 ROS-independent NETosis and inflammasome-related amplification loops Besides the classic oxidative stress pathways, studies indicate that MSU crystals can also directly induce histone citrullination and NET formation through the TAK1/SYK/PAD4 axis or by directly activating the NF-B pathway, thereby bypassing the classic ROS burst (110, 112)

Upon its accumulation and phosphorylation, HIF-1 dimerizes with HIF- (constitutively expressed nuclear proteins), enters the nucleus, and promotes the transcription of hypoxia response elements (HRE)-containing target genes involved in energy metabolism, erythropoiesis, vascular remodelling, and other processes (Fig

Eur J Clin Nutr 72 , 105111 (2018)