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Mutations in the KISS1 gene have been identified in humans and these mutations are associated with infertility, impaired puberty, and very low levels of gonadotropins and sex steroids

Validation of a liquid chromatography tandem mass spectrometry method to measure oxidized and reduced forms of glutathione in whole blood and verification in a mouse model as an indicator of oxidative stress

[DOI] [Google Scholar] 37.Chen S.-Y., Ho K.-J., Hsieh Y.-J., Wang L.-T., Mau J.-L

The protein biomarkers include cytoplasmic aconitate hydratase (ACO1), argininosuccinate synthase (ASS1), fumarylacetoacetase (FAH), fructose-1,6-bisphosphatase 1 (FBP1) and carbamoylphosphate synthase (CPS1) ( In the past decade, using biomarkers to predict, monitor and diagnose drug-induced diseases during drug treatment or clinical trials has gradually gained wide attention among professionals ( 3.2 Predictive models for screening DILI 32% of post-approval withdrawals and 22% of clinical trial failures are caused by drug hepatotoxicity ( in vitro models for DILI risk prediction