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Shaking creates foam, and foam means air-liquid interfaces where peptide molecules unfold and lose their three-dimensional structure

10.1186/s12935-020-1100-y 52 KongN.ChenX.FengJ.DuanT.LiuS.SunX.et al (2021)

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Many researchers describes ER stress-mediated disease progression as the second stage of alcohol-related liver disease as a result of upregulated ER stress inflammatory and steatosis pathways