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Laboratory investigations have reported measurable changes in nitric oxide related signaling markers, endothelial migration assays, fibroblast gene expression profiles, and cytoskeletal reorganization markers in cell culture and animal models

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The released ROS activate the ion channel TRPM2 in macrophages, promoting calcium influx, thereby eliciting an immune response

289 In addition, CD8 + T cell activation and recruitment were increased in the JHU-083 treatment model, and MDSCs generation and recruitment were significantly inhibited