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While previous reviews have often addressed these approaches separately, our synthesis brings together the most recent preclinical and clinical evidence, elucidates how oxidative stress is mechanistically linked to SASP activation, and critically evaluates pharmacokinetic and bioavailability challenges that influence therapeutic translation
Next-generation multi-agonist alternatives Tirzepatide was groundbreaking because it targeted two receptors (GLP-1 and GIP) instead of just one
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