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For standard titration starting at 0.25mg per week, the 2.0 mL option provides the best balance of measurement accuracy and vial longevity

Implications Resistance mechanisms that undermine the immunomodulatory effects of CD38targeting therapies can be tumor intrinsic, such as the downregulation of CD38 surface expression and expression of complement inhibitor proteins, and immune microenvironmentrelated, such as changes to the natural killer (NK) cell numbers and function in the bone marrow niche

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