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Indeed, despite the moderate doses of vitamin C used in this study, it is known that a high level might be pro-oxidant and increase free-radical damage [28]
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Since the Warburg effect was described, there has been an increase in research focusing on aerobic glycolysis (14) and there have been several attempts to limit the growth of lung cancer by cutting off its energy supply
However, unbiased genetic screens and biochemical studies have demonstrated that GPX4 is not the sole defense against ferroptosis
