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The development of chronic OIPN is likely to occur at cumulative doses exceeding 780850 mg/m 2 (4093% incidence), and can even last for several years [7, 15,16,17,18]

The forward signal occur when Eph/ephrin signal transduce into receptor-binding cell and the reverse signal when the ligand-receptor interaction leads to transduction into the ligand-expressing cell, reviewed in [155]

PCLS are now widely utilized to assess integrated cellular responses triggered by inflammatory, fibrotic, or infectious stimuli, as well as for investigating lung damage and regeneration ( in vivo exposed lungs and PCLS behavior and sensitivity to a wide panel of stimuli (physical, mechanical, chemical, pharmacological)

Supersensitivity to noradrenaline in vas deferens from morphine-dependent mice is confirmed