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Hepcidin, a major iron modulator and the endogenous protective molecule against ferroptosis ( Regulatory Pathways of Ferroptosis The mechanisms and genetic networks regulating ferroptosis are complex, and are still being elucidated
It alleviates the entire process of atherosclerosis (AS) by reducing oxidative stress, improving endothelial dysfunction, and inhibiting platelet activation and aggregation
TIMER analysis of TCGA database revealed that GPX4 is overexpressed in many cancers
ForsythCBShannonKMKordowerJHVoigtRMShaikhMJaglinJAet al
