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Figure 1 3 Mechanisms of psychological disorders in LC 3.1 Direct viral invasion Studies suggest that SARS-CoV-2 may persistently reside in tissue reservoirs within LC patients, triggering immune responses that contribute to symptom persistence ( 3.2 Immune dysregulation Research has demonstrated that COVID-19 induces an overactive immune response, with increased cytokine release associated with various psychiatric disorders ( 3.3 Neuroinflammation Neuroinflammation results from the interaction between the virus and the immune system, causing the release of pro-inflammatory cytokines that affect brain function and emotional regulation