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344 Similarly, miR-182-5p overexpression in hepatocytes increases cholic acid production by activating cholesterol 7 alpha-hydroxylase (CYP7A1), driving HSCs to secrete Hedgehog and stimulating hepatocyte proliferation following PHx

On the contrary, AOD 9604 is an investigational compound , and its side effects are not as well-documented
74,75 During DNA replication or transcription, ROS can chemically induce DNA missense mutations, truncation mutations, or even DNA breakage