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Zum Beispiel, weil einer dieser Prozesse zu viel NAD verbraucht: Wird die DNA-Reparatur berlastet, geht den Mitochondrien das NAD aus

Free Radic Biol Med 162:5364

However, the precise molecular mechanisms remain unclear, with emerging evidence suggesting lactate may indirectly modulate BK channel function via metabolic-epigenetic crosstalk, such as activating Sirtuin 1 (SIRT1) deacetylase through NAD+/NADH redox modulation or altering channel phosphorylation via AMPK signaling, thereby influencing potassium current properties (Shipston and Tian, 2016

Also, chrono-biotic hormone melatonin could effectively reduce ferroptosis through activation of Nrf2 and HO-1 signaling pathways 509