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Thereby, knockdown of Grx1 leads to increased levels of SLC7A11 and of GSH in lung cells [129]
However, the disconnect between ORR and mPFS suggests transient oncogene dependency, necessitating combinatorial strategies with HER2 degradation inducers (e.g., PROTACs) or immune checkpoint modulators to counteract compensatory pro-survival pathways
Hu et al., 2013
doi: 10.3389/fphys.2022.1036515 111 HuangYJNanGX
