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Increased NEFAs in cells compete with glucose for substrate oxidation, thus resulting in the inhibition of pyruvate dehydrogenase, phosphofructokinase, and hexokinase II [8]

Denn wahre Gesundheit bedeutet mehr als nur frei von Beschwerden zu sein sie bedeutet, sich wieder lebendig, ausgeglichen und voller Freude zu fhlen

Accordingly, several cellular hallmarks of proteotoxic stress have been identified, including dysregulated mTOR signaling and autophagy, compartment-specific unfolded protein response in mitochondria (UPR mt ), and in the endoplasmic reticulum (UPR ER )
