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From another point of view: while one active site requires a general acid, the other requires a general base

Neurosignals 8(12):7074 Hardeland R (2005) Antioxidative protection by melatonin

The potentiation effect of these components could help explain the differences in absorption of the same dose of histamine when ingested in isolation or in a food matrix [48,49]

Biological nanomedicines have emerged as a promising approach for combating CRC, offering advantages such as improved drug diffusion efficiency, ROS release, targeted therapy, and reduced drug resistance [165, 166]
