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Recently, the antipruritic effect of curcumin was found to be mediated through the Mas-related G-protein-coupled receptor B2 (MRGPRB2), the rodent homolog of the human MRGPRX2, as demonstrated by inhibition of C48/80-induced calcium influx in mouse peritoneal MC in a concentration-dependent manner

Specifically, a decrease in GSH levels and a drop in the GSH/GSSG ratio may indicate disease progression

Separate preclinical work examined BPC 157 as a therapy for disabled myotendinous junctions in rats (PMC8615275)
