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The BMK1/ERK5 is responsible for cell survival, differentiation and proliferation, angiogenesis, and antiapoptotic signaling

Diaf M, Khaled MB
Although ROS generation may not be an essential factor for aging (Lpez-Otn et al., 2013), they are more likely to exacerbate age-related diseases progression via oxidative damage and interaction with mitochondria (Dias et al., 2013)