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[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Trehy M.R., German A.J., Silvestrini P., Serrano G., Batchelor D.J

Rate of absorption (K a ) determines the time required for the administrated drug to the reach an effective plasma concentration and may, thus, affect the onset of drug effect

however, for pregnant and breastfeeding women, a higher dose is indicated, while 65 mg/day is recommended for teenage females

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