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Immunomodulatory effect of pentoxifylline during human allograft rejection: involvement of tumor necrosis factor-alpha and adhesion molecules

In the active group, the absolute values of the Japanese Rhino-conjunctivitis Quality of Life Questionnaire (JRQLQ) total score, Quality of Life (QOL) total score, sleep score, and physical score were significantly lower in the test food group than in the placebo group

doi: 10.1056/NEJM198012113032403

Vitamin B 12 is needed to prevent anemia, since making porphyrin and heme in mitochondria for producing hemoglobin in red blood cells depends on succinyl-CoA made by vitamin B 12