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Early multiorgan failure, thrombosis, intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension, in its full presentation (i.e., giant T-wave) or attenuated by BPC 157 therapy (i.e., normal T-wave) may be decisive for further isoprenaline-lesion development, similar to that noted with major intoxication (i.e., alcohol, lithium) or major vessel occlusion [14,15,16,17,18,19,20,21,22,23]

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Figure 1 Taken together, these results indicate that the treatment of sagittal brain slice cultures with 1 mM CPZ for 72 h induces demyelination within the corpus callosum, an effect that is not seen either when CPZ is co-administered with exogenous inflammatory stimulators, or in response to exogenous inflammatory stimulators alone